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ppsD [2019-09-16 12:34:54]
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ppsD [2019-09-16 12:34:54]

plipastatin synthetase
Locus
BSU_18310
Isoelectric point
5.35
Molecular weight
406.42 kDa
Protein length
3603 aa Sequence Blast
Gene length
10812 bp Sequence Blast
Function
production of the antibacterial compound plipastatin
Product
plipastatin synthetase
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
  • Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

    • Gene

    Coordinates
    1,964,045 → 1,974,856

    The protein

    Protein family

  • ATP-dependent AMP-binding enzyme family (according to UniProt)

    • Paralogous protein(s)

  • partial match (more than 1,000 amino acids): DhbF, PksJ, PksN, PpsA, PpsB, PpsE, SrfAC

    • Structure

  • 2VSQ (termination module of SrfAC, 38% identity) PubMed

    • Expression and Regulation

    Operons

    Genes
    ppsA-ppsB-ppsC-ppsD-ppsE
    Description
    PubMed

    Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon
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    Biological materials

    Mutant

  • BKE18310 (ΔppsD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCATGTCTCCTGTCA, downstream forward: _UP4_ATGCTCAGTTTTCACTAATG
  • BKK18310 (ΔppsD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCATGTCTCCTGTCA, downstream forward: _UP4_ATGCTCAGTTTTCACTAATG

    • References

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